In a study of HSV-1 infection of B cells, Neumann et al. evaluated the total amount of CD74, DR, and DM at different times after HSV-1 infection, and showed that the expression of CD74 was dramatically reduced in infected cells from 18 h post-infection, falling to less than 15% at 64 h post-infection compared to uninfected cells, while the total cell levels of HLA-DR and -DM remained unaffected [79]. This evidence concerns the gene CD74 and infection.