Moreover, the suppressed expression of 14-3-3σ and Maspin and enhanced expression of GRP78 and Mn-SOD were observed to be correlated with NPC radioresistance with a sensitivity of 90% and a specificity of 88% in the 39 radioresistant and 51 radiosensitive NPC tissues by immunohistochemistry [51]. The gene discussed is HSPA5; the disease is nasopharyngeal carcinoma.