NPPB and hydrops fetalis: MMP-2 and sTNF-R1 are potent predictors of cardiovascular events and mortality in HF patients, and these biochemical markers used in conjunction with other established markers as NT-proBNP, that is, a powerful predictor of mortality in HT [22], may also help to identify patients with no clinical evidence of HT, and provide information about the need for changes in treatment during different stages of the disease, and potentially it could provide valuable biochemical data for the specialist.