TNF and inflammatory response: Oxidative stress like hydrogen peroxide (H2O2), superoxide and hydroxyl radicals, and proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha have been shown to induce acinar cell injury and to be involved in the progression of this illness from acinar cell injuries to a fetal systemic reactions, where oxygen free radicals and lipid peroxidation play important roles in the development of pancreatic inflammation [4].