In our study, more females than males were affected by oral HIV-KS and although not statistically significant, females had a lower average CD4+ T-cell count (85 cells/mm3) than males (141 cells/mm3) at the time of oral HIV-KS diagnosis, in line with other studies documenting that females with HIV-KS have more severe immunodeficiency than males with HIV-KS [39]. This evidence concerns the gene CD4 and immune system disorder.