Although previous studies suggested that successful SIT treatment is often accompanied with an increased IFN-γ, there are a growing number of research reports indicating that IFN-γ secreted by CD8+ T cells will further aggravate asthma disease severity, therefore, it has been questioned that IFN-γ can improve Th2-dominated inflammatory response in patients with asthma [11]. The gene discussed is IFNG; the disease is asthma.