Tumor-related genes p16, p14, E-cadherin, PTEN (phosphatase and tensin homolog deleted on chromosome ten), RASSF1A (Ras association domain family 1A), GSTP1 (Glutathione S-transferase pi 1), MGMT (O (6)-methylguanine-DNA-methyltransferase), and MINT2 (Munc18-1-interacting protein 2) are hypermethylated in EBVaGC [9–11], suggesting that EBV-related aberrant methylation may play an important role in development of EBVaGC. Here, CDKN2A is linked to neoplasm.