In a previous study, we demonstrated that NM significantly (p<0.05) reduced bFGF-induced angiogenesis [utilizing a chorioallantoic membrane (CAM) assay in chick embryos], and decreased the human U2OS osteosarcoma cell expression of VEGF, angiopoietin-2, bFGF, PDGF and TGFβ-1 (4). Here, ANGPT2 is linked to osteosarcoma.