Namely the mutant AKT1 gene has: 1) an altered PH domain conformation, 2) is constitutively-active, 3) has an altered cellular distribution as it is constitutively-associated with the cell membrane, 4) morphologically transforms Rat-1 tissue culture cells and 5) interacts with c-Myc to induce leukemia in E-mu-Myc mice (E-mu = Enhancer of immunoglobulin mu gene, Myc = Myc oncogene originally isolated in avian myelocytomatosis virus) [357]. Here, MYC is linked to leukemia.