During the last decade, a number of genetic variants have been examined for their association with type 2 diabetes, and a consistent association has been found for peroxisome proliferator-activated receptor-γ2 (PPARG2).7 A recent meta-analysis reported that the PPARG2 Pro12Ala polymorphism was associated with a reduction in type 2 diabetes risk and that this association did not differ between Asians and whites.7 However, the interactions between this polymorphism and known clinical risk factors (including family history of diabetes) for type 2 diabetes risk are not well understood. This evidence concerns the gene PPARG and diabetes mellitus.