In summary, our GWAS in LCLs, together with translational studies with DNA samples from lung cancer patients, followed by functional studies in lung cancer cell lines showed that 6 genes, PIP4K2A, CCT5, CMBL, EXO1, KMO and OPN3, genes that are close to 3 SNPs associated with SCLC overall survival (rs1778335, rs2662411 and rs7519667), significantly altered paclitaxel cytotoxicity in the SCLC cell line, H196. This evidence concerns the gene CCT5 and small cell lung carcinoma.