OPN3 and small cell lung carcinoma: As shown in Figure 3 and Table 3, MTS assay indicated that knockdown of PIP4K2A, CCT5, CMBL, EXO1, KMO and OPN3, which were close to SNPs rs1778335, rs2662411 and rs7519667, significantly desensitized paclitaxel-induced cytotoxicity in the SCLC cell line H196, and those 3 SNPs were also associated with SCLC overall survival with p-value < 0.05 (Table 2).