Knockdown of PIP4K2A, CCT5, CMBL, EXO1, KMO and OPN3, 6 genes that were close to the 3 SNPs (rs1778335, rs2662411 and rs7519667) associated with SCLC overall survival, significantly desensitized H196 cells to paclitaxel (Figure 3). The gene discussed is KMO; the disease is small cell lung carcinoma.