CDK4 and hepatocellular carcinoma: Activations of CDK2 and CDK4, which are transient patterns that only occur after a certain period successive to HCV infection, were clearly identified in the dysplastic network, as shown in Figure 6C. Transient patterns were also observed in the early HCC network, including activation of the HDAC and EP300 module and the PCNA module, suggesting that the tissue was evolving towards HCC.