TP53 and infection: A similar but less dramatic lifespan extension was seen for AG17524(RTS) cells (Fig. 3); when infected at PD 26.5, the puromycin-resistant control clones managed an average post-infection lifespan of 1.31 ± 0.67 PDs before reaching M1, compared to 6.52 ± 1.82 PDs for shRNA-expressing AG17524(RTS)p53 cells at Mint (p < 2.9 × 10−8; Student’s t test).