However, GHS-R immunoreactivity was significantly lower (p < 0.05) in both canine mammary carcinomas isolated from primary tumors than in cell lines isolated from their metastases to the lungs: 5230 ± 399.5 and 6729 ± 462.7 in CMT-W1 and CMT-W1M cell lines, respectively and 6189 ± 433.0 and 7792 ± 401.9 in CMT-W2 and CMT-W2M cell lines, respectively (Figure6A, B). This evidence concerns the gene GHSR and breast carcinoma.