Thus, regarding the role of IL-17RC and/or the IL-17 cytokine/IL-17R signaling axis in disc and bone destruction, the rs708567 polymorphism may impair the function of the IL-17RC gene and accelerate disc degeneration and bone destruction, which may lead to the occurrence and progression of scoliosis. The gene discussed is IL17RA; the disease is intervertebral disk degenerative disorder.