Phospho-tau pathology as seen in Atg7-deficient animals may broadly relate to neuronal dysfunction in neurodegeneration, as macroautophagy deficiency and phospho-tau are commonly observed in a broad array of neurodegenerative disorders including AD, PD, tauopathy, huntington disease, amyotrophic lateral sclerosis, and Gaucher disease[6,46-49]. Here, ATG7 is linked to amyotrophic lateral sclerosis.