In addition, under HG conditions with increased TNF-alpha levels, the death receptors TNF-R1 and Fas, are up-regulated in human coronary artery endothelial cells, which could in turn play a role in HG-induced endothelial cell apoptosis and hyperglycemia appears to be a risk factor for vascular calcification[14-16]. The gene discussed is TNFRSF1A; the disease is Hyperglycemia.