However, as suggested by the lack of recurrence of vascular disease in transplanted kidneys[1,2], we observed onset of vascular ischemia prior to the onset of hypertension and renal failure in some SIOD patients, no detectable inflammatory infiltrate in the aortic wall, and altered distribution of tropoelastin and elastin in a 15-week gestation SIOD fetus. Here, ELN is linked to hypertensive disorder.