Therefore, in the present study, we evaluated 1) the association between the tumor characteristics of 176 cases of UTUC and the expression of TS and DPD by immunohistochemistry with slides re-reviewed by genitourinary pathologists to determine the clinical role of TS and DPD expression in tumor progression and survival in UTUC. This evidence concerns the gene DPYD and renal pelvis/ureter urothelial carcinoma.