The basal-plus approach to insulin intensification in persons with Type 2 diabetes seems to be a promising alternative to the current options of either twice-daily premixed insulin or a full basal–bolus strategy, thereby providing a viable intermediate step between basal only and basal–bolus strategies, as recommended in the latest version of the ADA/EASD consensus guidelines (Fig. 2) 19. This evidence concerns the gene INS and type 2 diabetes mellitus.