For example, samples GSM383929 and GSM180669 were excluded since these did not satisfy criteria (i), representing ovary surface epithelium immortalized with SV40 and lymphocytes from Down syndrome children, respectively; samples GSM384024 (white blood cells, CD45+, isolated from a mammary gland carcinoma; 18,741 tags) and GSM1128 (breast cancer cell line; tags detected once are not available) were excluded as not satisfying criteria(ii) and (iii), respectively (Supplementary Table 1). Here, PTPRC is linked to Down syndrome.