TIMP1 and Hepatic fibrosis: In a recent study, ginsenoisde Rb1 significantly inhibits liver fibrosis by inhibiting activation, proliferation, and expression of collagen, transforming growth factor-β1 (TGF-1), matrix metalloproteinase (MMP)-2, and tissue inhibitor of metalloproteinase (TIMP)-1 in hepatic stellate cells, the major cause of liver fibrosis, at 10–80 μg/mL [63].