Activated PTHLH coupling feedback phosphoinositide to G-protein receptor signal network included BUB1B, GNG10, PTHR2, GNAZ, PTHR2, BUB1B, RFC4, and UBE2C and activated PTHLH feedback cell adhesion network NRXN3, BAP1, NRXN3, PVRL2, TROAP, and  VCAN in HCC, as shown in Figures 1 and 2. Here, BUB1B is linked to hepatocellular carcinoma.