By immunoblot analysis,(Additional file1) we observed strong PRL-3 protein expression in two human CML cell lines (K562 and KCL-22, Figure1B), murine hematopoitic cells expressing WT and mutant BCR-ABL constructs (P210 WT, P210 T315I, P210 M351T and P210 H396R, Figure1B middle), and primary BM samples from CML patients (Figure1B right). The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.