Levels of circulating inflammatory markers, including high sensitivity C reactive protein (hsCRP), tumor necrosis factor α (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6), soluble intracellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) et al., were elevated in patients with CHF, serving as prognostic markers or therapeutic targets[11-14]. The gene discussed is TNF; the disease is congestive heart failure.