However, IL-1β and IL-6 were higher in CRC (IL-1β: 7.3 ± 0.6 pg/ml, P < 0.001; IL-6: 25.6 ± 2.6 pg/ml, P = 0.001) but highest in CRA (9.3 ± 0.6 pg/ml, P < 0.001; 33.9 ± 2.1 pg/ml, P < 0.001 ) as compared with healthy controls (4.6 ± 0.2 pg/ml; 11.2 ± 2.3 pg/ml). This evidence concerns the gene IL1B and colorectal carcinoma.