However, we found that the tissues of the advanced CRC released significantly higher amount of IL-1β (2305.8 ± 618.8 pg/mg tissue vs 822.2 ± 240.9 pg/mg tissue, P = 0.044) than the tissues of the early CRC, while the release of IL-6 (4365.9 ± 317.1 pg/mg tissue vs 3026.2 ± 506.3 pg/mg tissue, P = 0.048) was significantly higher from the early CRCs than from the advanced CRCs. The gene discussed is IL1B; the disease is colorectal carcinoma.