If one examines the HFD downregulated genes that were upregulated in HFD+BB versus HFD (222, 12), the apoptosis pathway (four genes, p=0.081, 3.9 fold enrichment) was shown with a probe for tumor necrosis factor-alpha (TNF-α) also recognized in the SLE pathway. The gene discussed is TNF; the disease is systemic lupus erythematosus.