The survival benefit observed in mice treated with anti-CXCR3 IgG 2 hours or 6 hours after the initiation of severe sepsis was similar to that seen in mice treated with anti-CXCR3 24 hours prior to CLP and was associated with attenuation of sepsis-induced hypothermia and systemic cytokine production. Here, CXCR3 is linked to Sepsis.