Particular attention deserves the upregulation of selectin-E (SELE) and IL8 (Table 1); indeed Hall et al. [27] demonstrated that patients with DH have an increased serum level of IL-8 that is associated with cutaneous endothelial cell activation and increased expression of SELE [28]. This evidence concerns the gene CXCL8 and dermatitis herpetiformis, familial.