Since the ErbB receptor family has many negative feedback mechanisms (e.g., receptor endocytosis, phosphorylation, and ubiquitination/deubiquitination) and crosstalk with other pathways (such as NOTCH pathways, VEGF, and TGF-β), components of the EGFR/ErbB network are excellent targets for cancer therapy [57]. This evidence concerns the gene TGFB1 and cancer.