Wolcott–Rallison syndrome (WRS, OMIM#226980) is a rare autosomal recessive condition characterized by permanent neonatal diabetes, epiphyseal dysplasia, hepatic dysfunction, and renal impairment and is caused by mutations in the EIF2AK3 gene [Delepine et al., 2000]. The gene discussed is EIF2AK3; the disease is Wolcott-Rallison syndrome.