As a consequence of Aβ-RAGE interaction, activation of p38 mitogen-activated protein kinases (p38MAPK), stress-activated protein kinase or c-Jun N-terminal kinase (SAPK/JNK), and nuclear factor κB (NFκB) signaling transduction was seen in synaptic failure of sporadic AD cybrids [15]. Here, AGER is linked to Alzheimer disease.