VEGFA and neoplasm: One of the major problems during anti-VEGF treatment seems to be tumor evasion from VEGF blockage that may involve several complex escape mecha-nisms [12,13,19,20] including activation of other pro-angiogenic factors such as the fibroblast-growth factor (FGF) and/ or the platelet-derived growth factor (PDGF) system [12,13,19-21].