These molecular changes were best captured at 24 h and Western blots for 3 patients with SLL/CLL and 1 with MZL lymphoma are shown in Figure 2A. A statistical analysis summary for changes in the induction of p53-target proteins following exposure to HDM2 SMIs in patient samples is shown in Figure 2B. This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.