Elevated levels of proinflammatory cytokines such as IL-1β, IL-6, IL-17, IL-8, IL-18, and TNF-a were previously described in AOSD patients, often in association with disease activity and/or distinct clinical phenotypes and serological feaures such as hepatic involvement, arthritic complaints, salmon rash, and hyperferittinimia among others [15–21]. This evidence concerns the gene IL6 and adult-onset Still disease.