The test demonstrated an insufficient response with an increase from baseline plasma cortisol of 222 pmol/L (190–600 pmol/L) to 239 pmol/L (>500 pmol/L) after 30 minutes and an elevated plasma ACTH of 75 pmol/L (2–11 pmol/L), indicating a primary adrenal insufficiency. The gene discussed is POMC; the disease is Adrenal insufficiency.