In the case of CW, the in vitro data showed 57% inhibition on hOAT1-mediated transport (Table 1), the in vivo data showed significant reduction in CLPAH and CLsec  PAH (Table 3), whereas the expression of rOAT1 mRNA remained still in comparison to control group (Figure 5). Here, SLC22A6 is linked to pulmonary arterial hypertension.