Liu et al. (2009) analyzed gene expression and genome-wide binding of cohesin in lymphoblastoid cell lines from CdLS probands with mutations in NIPBL or in the cohesin subunit SMC1A, and found that ∼1500 genes (FDR ≤ 0.05) were dysregulated compared with controls. This evidence concerns the gene NIPBL and Cornelia de Lange syndrome.