More recently, p53 has been assigned an important regulatory role in glutamine metabolism and in maintaining the balance between glycolysis and oxidative phosphorylation (Hu et al., 2010; Suzuki et al., 2010; Vousden, 2010), leading Wise and Thompson to propose that “glutamine addiction” could offer a new therapeutic target for cancer (Wise and Thompson, 2010). The gene discussed is TP53; the disease is cancer.