In order to evaluate whether the mouse fibroblast model of K-ras-induced transformation, used in many of the characterization experiments of enhanced cell growth discussed so far, can be considered a representative model of molecular events taking place in human tumors, we run a comparative gene expression profile analysis (Balestrieri et al., 2012) over a set of human cancer cell lines (NCI-60 cell collection). This evidence concerns the gene KRAS and cancer.