Conversely, some have argued that aCL assays detectclinically significant antibodies which are not detected by aβ2GPI assays.4,6,7 Secondly, a significant proportion of our cohort (37%) had purely obstetric APSwhereas many published studies have included only patients with a history of thrombosis.Much of the published literature on aPL phenotypes in APS relates to patients withSLE-associated APS, whereas in the patients in our cohort only a minority (19/145) had SLE,as the study cohort comprised patients who had predominantly presented to haematology ratherthan rheumatology clinics. This evidence concerns the gene FASLG and Venous thrombosis.