The antiphospholipid syndrome (APS) is characterized by thrombotic and/or pregnancymorbidity associated with the presence of persistent antiphospholipid antibodies (aPLs).1 There are many other clinical manifestations associated with persistent aPL(including immune thrombocytopenia, livedo reticularis, migraine, valvular heart disease andcognitive dysfunction), and, while these conditions are not considered diagnostic for APS,they are frequently encountered and require clinical attention. The gene discussed is FASLG; the disease is autoimmune polyendocrinopathy.