Wahl et al. suggested that modifications of the serological criteria for the diagnosis ofAPS should in the future be based on new data and on appropriate systematic reviews.8 The proposed entity of seronegative APS, where patients have characteristic clinicalmanifestations of APS but lack conventional serological markers, has also been givenconsideration in classification criteria for APS.11 We report on serological criteria in a cohort of patients diagnosed to have APS,based on a comprehensive methodological approach which included testing for LA as well asIgG and IgM aCL and aβ2GPI. This evidence concerns the gene CD40LG and autoimmune polyendocrinopathy.