ACLY and autoimmune polyendocrinopathy: We and others have previously reported that omission ofaCL testing from the clinical investigation of APS could lead to a failure to diagnose thesyndrome in a proportion of patients,6–8 and, in a multicentre prospective European women cohort, isolated aCL and/oraβ2GPI positivity was found in a proportion of women with obstetric APS.7 The cut-off for serological positivity is also contentious.