As for transferrin saturation levels, in 5 studies involving 6194 cases of CHD, a comparison of individuals in the top versus bottom tertile of the baseline measurement yielded a combined risk ratio of 0.9 (95% CI, 0.7–1.1).8 In contrast, a 13-year follow-up study consisting of 4237 residents aged 40 to 74 years showed that serum iron was inversely associated with risk of myocardial infarction: the multivariable relative risk associated with an increase of 5.4 μmol/L in serum iron concentration was 0.82 in women (95% CI, 0.70–0.95) and 0.92 (0.85–1.00) in men.17 This evidence concerns the gene TF and myocardial infarction.