AGPS and Alzheimer disease: Significantly, patients with sporadic AD were recently shown to exhibit defects in the clearance of Aß (rather than increases in its production) [8] and, in light of the large body of evidence implicating AßDPs in the regulation of cerebral Aß levels [7], it is reasonable to infer that defects in one or more AßDPs could contribute to impaired Aß clearance.