A single center, randomized, double-blind, placebo-controlled study, Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction (HARP), investigated simvastatin (80 mg for up to 14 days) in 60 patients with ALI [11]. Here, HMGCR is linked to acute respiratory distress syndrome.