The differences observed between methylation of the regions CASP8 A1 and CASP8 A2 in reference adrenal medullary DNA are striking: the region CASP8 A1, while abundantly methylated in neuroblastomas (mean methylation 16.2%; 21 tumors over cut-off), was devoid of methylation in reference adrenal medulla. The gene discussed is CASP8; the disease is neuroblastoma.