In the seven neuroblastoma cell-lines analyzed hypermethylation was present in BLU, CASP8, DCR2, CDH1, RASSF1A and RASSF2, but was not observed for APC, DAPK1, NORE1A, P14, P16, TP73, PTEN or RARB (Table2). The gene discussed is CASP8; the disease is neuroblastoma.