CASP8 and neuroblastoma: Teitz et al. indicated that this could signify that inactivation of the Fas apoptotic pathway is needed for the survival of neuroblastoma cells expressing high levels of MYCN. A contrasting view was presented by Banelli et al. who did not find correlation between CASP8 silencing and MYCN amplification, although higher frequencies of methylation were detected in MYCN-amplified cells[29].