Previous studies which have shown upregulation and/or amplification of the LAPTM4B gene in a variety of human cancers, and this together with experimental evidence showing that malignant phenotypic features can be induced or reversed by transfection or knockdown respectively of LAPTM4B strongly suggests that this gene plays a fundamental role in the neoplastic mechanism(s) of these tumors [17], [19], [22]. Here, LAPTM4B is linked to cancer.