LAPTM4B and metastatic malignant neoplasm in the lymph nodes: Multivariate Cox regression analysis revealed that LAPTM4B genotype (RR, 2.809, 95%CI, 1.506-5.240, P = 0.001), lymph node metastasis (RR, 2.937, 95%CI, 1.519-5.679, P = 0.001) and TNM stage (RR, 2.857, 95%CI, 1.214-6.721, P = 0.016) are prognostic markers for overall survival in patients with GBC (Table 3; P<0.05).