AD brain pathology is characterized by the extracellular deposition of amyloid β 1–42 (Aβ1–42) in amyloid plaques and the intracellular aggregation of hyperphosphorylated tau protein in neurofibrillary tangles (NFTs), all embedded in an environment of activated glial cells [12], [13], [14]. Here, MAPT is linked to Alzheimer disease.