HBEGF and cardiac hypertrophy: Moreover, HB-EGF is involved in a number of physiological and pathological processes, including heart development and maintenance [8], skin wound healing [9]–[11], eyelid formation [12], cardiac hypertrophy [13], smooth muscle cell hyperplasia [14], kidney collecting duct morphogenesis [15], blastocyst implantation [16], [17], pulmonary hypertension [18], and oncogenic transformation [19].