The most highly significant signature gene SNP in AAs was rs629508 (P = 1.7×10−3) in SESN3, whereas in EA cases, the most significant SNP was rs2618134 (P = 4.7×10−5) in RBM12B. Interestingly, several SNPs were also significantly associated with complicated sarcoidosis, including rs629508 (P = 5.4×10−5) and rs1294689 (P = 3.6×10−5) in the AA samples and rs10485815 (P = 2.8×10−5) in the EA samples (Table 5). The gene discussed is SESN3; the disease is sarcoidosis.