CHD1 and melanoma: This finding is in agreement with the data reported earlier that melan-a melanocytes and 4C11+ metastatic melanoma cells display an epithelial morphology, whereas 4C pre-malignant melanocytes and 4C11− non-metastatic melanoma cells exhibit a mesenchymal morphology with enhanced expression of the gene Chd1, and the presence of the repressive histone mark H3K27 trimethylation plus the active mark H3K4 trimethylation [11].