Hypopituitarism is generally a chronic and life-long disease involving deficiencies in one or more of the six pituitary hormones: growth hormone (GH), thyroid stimulating hormone (TSH), adrenocorticotrophic hormone (ACTH), luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL). This evidence concerns the gene PRL and hypopituitarism.